|
KMID : 0378019730160120077
|
|
New Medical Journal
1973 Volume.16 No. 12 p.77 ~ p.87
|
|
|
Studies on Cardiotonic Effect of Aconiti Tuber
|
|
|
|
|
Abstract
|
|
|
Aconiti Tuber, one of Hellaboraceae Family, has been widely used as tonic in the sphere of Chinese Medicine and its hot water extract is still used as analgesic.
The pharmacologic actions of its alkaloids, specially aconitine and mesaconitine, are well known.
´Isaku reported that its fraction insoluble in CHC13 (alkaloid free fraction) showed inotropic effect on isolated frog´s heart and its effect didn´t change even after boiling on water bath for a few hours. (1958).
Five different fractions from Aconiti Tuber were prepared and their effects on= excised frog´s heart and their systemic effect in rabbit with respect to their inotropic effect, chronotropic effect and toxicity were studied, and comparison with ouabain and epinephrine was done.
The results -are as follows.
1. CHC13 insoluble fraction showed the inotropic effect as Isaku mentioned, and the inotropic effect of that fraction was potentiated by n-butanol fractionation.
2. The alkaloid free fractions didn´t show any noticeable chronotropic effect either in vitro or in vivo.
3. Alkaloid free fractions did not produce cardiac arrhythmia either in vitro or in vivo at one thousand fold of the concentration, at which initially detectable inotropic effect appeared. 4. At least, the inotropic effect of alkaloid free fraction doesn´t seem to be caused by epinephrine.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|